3-D printed organs aid vaccine testing

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3-D printed organs aid vaccine testing

18 August 2020
News
As shortages of personal protective equipment persist during the coronavirus pandemic, 3-D printing has helped to alleviate some of the gaps. But Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, and his team are using the process in a more innovative way: creating tiny replicas of human organs — some as small as a pinhead — to test drugs to fight COVID-19.

The team is constructing miniature lungs and colons — two organs particularly affected by the coronavirus — then sending them overnight for testing at a biosafety lab at George Mason University in Fairfax, Va. While they initially created some of the organoids by hand using a pipette, they are beginning to print these at scale for research.

 

The process of constructing human tissue this way is a form of bioprinting. While its use in humans is years away, researchers are honing the methods to test drugs and, eventually, to create skin and full-size organs for transplanting. Researchers are making strides in printing skin, critical for burn victims; managing diseases like diabetes in which wound healing is difficult; and for the testing of cosmetics without harming animals.

“The 3-D models can circumvent animal testing and make the pathway stronger from the lab to the clinic,” said Akhilesh Gaharwar, who directs a cross-disciplinary lab in the biomedical engineering department at Texas A&M University that focuses on bioprinting and other approaches to regenerative medicine.